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KMID : 1141320170320020233
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Kosin Medical Journal
2017 Volume.32 No. 2 p.233 ~ p.239
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IgG4-Related Disease with lymphadenopathy Presenting as a Cervical lymph node enlargement
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Choi Yeon-Seok
Kim Sung-Min
Sohn Jang-Sihn
Hwang Ji-Yong
Chang Tae-Soo
Cho Do-Yeon
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Abstract
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During the course of evaluation and management of neck masses, consideration for Immunoglobulin G4-related disease (IgG4-RD) should be given. IgG4-RD is relatively a new growing entity of immune-mediated origin, characterized by a mass-forming lesion, the infiltration of IgG4-positive plasma cells and occasionally elevated serum IgG4. The most common manifestations are parotid and lacrimal swelling, lymphadenopathy and autoimmune pancreatitis.
A previously healthy 72-year-old man was referred to our clinic with a 2-month history of left cervical lymph node enlargement without systemic manifestations . A cervical lymph node biopsy was planned because of elevated serum IgG4 levels. Pathological findings showed prominent infiltration of IgG4-postive plasma cells in the lymph node. After steroid therapy, a computed tomography scan revealed a decrease in the cervical lymph node size.
This case illustrates the importance of including IgG4-RD in the differential diagnosis of a cervical lymph node enlargement.
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KEYWORD
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Immunoglobulin G4, Lymphadeopathy
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